Sodium ascorbate [134-03-2]
Referência B1834-1g
Tamanho : 1g
Marca : APExBIO Technology
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Sodium ascorbate
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 198.11 |
| Cas No. | 134-03-2 |
| Formula | C6H7NaO6 |
| Solubility | ≥44.2 mg/mL in DMSO; ≥2.82 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | sodium (R)-2-((S)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate |
| SDF | Download SDF |
| Canonical SMILES | O=C1C(O)=C([O-])[C@@H]([C@@H](O)CO)O1.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
| Cell lines | Human glioblastoma multiforme (GBM), rat prostate cancer (PC) and normal mouse 3T3 cells |
| Reaction Conditions | 1 ~ 14 mM sodium ascorbate |
| Applications | Sodium ascorbate considerably decreased the proliferation and motility of GBM and PC cells. This effect was accompanied by intracellular ROS over-production and necrotic death of tumor cells, apparently resulting from their "autoschizis". |
| Animal experiment:[1] | |
| Animal models | Male Wistar rats, 200 ~ 230 g |
| Dosage form | 1 or 2 mg/kg Injected intravenously at 3rd and 7th day after U87 cell implantation |
| Applications | In U87 tumor-bearing rats, intravenous administration of sodium ascorbate inhibited tumor invasion in vivo and seemed to reduce the size of neoplasia. Concomitantly, blood analyses did not show any signs of hemolysis or biochemical disorders after sodium ascorbate administration. High doses of sodium ascorbate were demonstrated to interfere with the expansion of GBM cells in vitro and in vivo. |
| Note | The technical data provided above is for reference only. |
| References: 1. Ryszawy D, Pudełek M, Catapano J, et al. High doses of sodium ascorbate interfere with the expansion of glioblastoma multiforme cells in vitro and in vivo. Life Sciences, 2019, 232: 116657. | |