Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein.

Synonyms:
1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-,(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl ester, (2S)-2-Piperidinecarboxylic Acid

Molecular Formula:
C42H56N2O10

Molecular Weight:
748.9

Appearance:
White to off-white solid

Purity:
≥99%

Solubility:
Chloroform (Slightly), Methanol (Slightly)

Method for Determining Ientity:
Proton NMR Spectroscopic and Mass Spectrometric analysis

TLC Conditions:
SiO2; Dichloromethane:Methanol=9:1; Visualized with UV and KMnO4; Single Spot, Rf=0.75

Elemental Analysis:
Calculated: %C: 67.36, %H: 7.54, %N: 3.74

Specific Rotation (c=0.2, Methanol):
As Reported

Storage and Stability:
Store at 4°C. Hygroscopic; Store under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.