Selenomethionine [1464-42-2]

Imprimir

Referência NB-64-07638-50mg

Tamanho : 50mg

Contactar o distribuidor local :

Telefone : +1 850 650 7790

Marca : Neo Biotech

Solicitar mais informações

Contactar o distribuidor local :

Telefone : +1 850 650 7790

Selenomethionine (Synonyms: Seleno-DL-methionine, DL-Selenomethionine)

Catalog No. T1658 Copy Product Info

Purity: 99.95%

DL-Selenomethionine (Seleno-DL-methionine) is a selenium (Se) analogue of methionine in which sulfur is replaced with the trace element selenium. Selenomethionine (SeMet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues.

Selenomethionine

Copy Product Info

Synonyms Seleno-DL-methionine, DL-Selenomethionine

Cas No. 1464-42-2

Batch Information

Select Batch

Purity:99.95%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Selenomethionine AI Summary

Selenomethionine exhibits a diverse range of bioactivities, demonstrating notable inhibitory effects across several targets. It functions as a modulator of Lamin A splicing with a potency of 631.0 nM and as an inhibitor of Aldehyde Dehydrogenase 1 (ALDH1A1) at 39810.7 nM. It also inhibits Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 50118.7 nM and Histone Lysine Methyltransferase G9a at 17782.8 nM. Additionally, Selenomethionine is an inhibitor of the malarial parasite plastid at 1694.4 nM and shows inhibitory effects against Trypanosoma Brucei at 7943.3 nM. It significantly inhibits Plasmodium falciparum (3D7) proliferation with a potency of 43.2 nM, Plasmodium falciparum (DD2) with potencies of 6.9 nM and 153.4 nM in different assays, and Plasmodium falciparum (HB3) at 27282.4 nM. In terms of antiviral activities, Selenomethionine inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours with an inhibition rate of 9.25%. It also displays inhibition of the SARS-CoV-2 3CL-Pro protease by 9.2% at a 20 µM concentration based on a FRET assay. Additionally, the compound inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours of exposure to 0.01 MOI of the virus, with an observed inhibition percentage of 0.02%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DL-Selenomethionine (Seleno-DL-methionine) is a selenium (Se) analogue of methionine in which sulfur is replaced with the trace element selenium. Selenomethionine (SeMet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues.
Synonyms	Seleno-DL-methionine, DL-Selenomethionine

Chemical Properties

Molecular Weight	196.11
Formula	C₅H₁₁NO₂Se
Cas No.	1464-42-2
Smiles	C(C(O)=O)(CC[Se]C)N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1.96 mg/mL (10 mM, insoluble or slightly soluble)

H2O: 11.9 mg/mL (60.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.0992 mL	25.4959 mL	50.9918 mL	254.9590 mL
5 mM	1.0198 mL	5.0992 mL	10.1984 mL	50.9918 mL
10 mM	0.5099 mL	2.5496 mL	5.0992 mL	25.4959 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.2550 mL	1.2748 mL	2.5496 mL	12.7479 mL
50 mM	0.1020 mL	0.5099 mL	1.0198 mL	5.0992 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.