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Rimantadine (hydrochloride) [1501-84-4]

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Referência HY-B0338A-100mg

Tamanho : 100mg

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Marca : MedChemExpress

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Telefone : +1 850 650 7790

Rimantadine hydrochloride is an anti-influenza virus drug.

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Rimantadine hydrochloride Chemical Structure

CAS No. : 1501-84-4

This product is a controlled substance and not for sale in your territory.

Description

Rimantadine hydrochloride is an anti-influenza virus drug. Target: Influenza Virus Rimantadine hydrochloride are oral antiviral drugs useful in the prophylaxis and treatment of influenza A virus infections. rimantadine has prophylactic efficacy comparable to amantadine but lower potential for causing adverse effects [1]. double-blind study of children with influenza-like illness. 37 received rimantadine for five days. Of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) [2].

Essai clinique

Masse moléculaire

215.76

Formule

C₁₂H₂₂ClN

CAS No.

1501-84-4

Appearance

Solid

Color

White to off-white

SMILES

CC(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)N.Cl

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (231.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 33.33 mg/mL (154.48 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6348 mL	23.1739 mL	46.3478 mL
5 mM	0.9270 mL	4.6348 mL	9.2696 mL
10 mM	0.4635 mL	2.3174 mL	4.6348 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (154.48 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: ≥98.0%

Select Batch:

Fiche technique (278 KB) SDS (393 KB)

COA (257 KB) HNMR (249 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Hall, C.B., et al., Children with influenza A infection: treatment with rimantadine. Pediatrics, 1987. 80(2): p. 275-82. [Content Brief]

[2]. Tominack, R.L. and F.G. Hayden, Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infect Dis Clin North Am, 1987. 1(2): p. 459-78. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.6348 mL	23.1739 mL	46.3478 mL	115.8695 mL
	5 mM	0.9270 mL	4.6348 mL	9.2696 mL	23.1739 mL
	10 mM	0.4635 mL	2.3174 mL	4.6348 mL	11.5869 mL
	15 mM	0.3090 mL	1.5449 mL	3.0899 mL	7.7246 mL
	20 mM	0.2317 mL	1.1587 mL	2.3174 mL	5.7935 mL
	25 mM	0.1854 mL	0.9270 mL	1.8539 mL	4.6348 mL
	30 mM	0.1545 mL	0.7725 mL	1.5449 mL	3.8623 mL
	40 mM	0.1159 mL	0.5793 mL	1.1587 mL	2.8967 mL
	50 mM	0.0927 mL	0.4635 mL	0.9270 mL	2.3174 mL
	60 mM	0.0772 mL	0.3862 mL	0.7725 mL	1.9312 mL
	80 mM	0.0579 mL	0.2897 mL	0.5793 mL	1.4484 mL
	100 mM	0.0463 mL	0.2317 mL	0.4635 mL	1.1587 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Rimantadine hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rimantadine1501-84-4Influenza VirusInhibitorinhibitorinhibit

Rimantadine (hydrochloride) [1501-84-4]

Referência HY-B0338A-100mg

Contactar o distribuidor local :

Marca : MedChemExpress

Contactar o distribuidor local :

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Rimantadine hydrochloride Related Classifications

Keywords:

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