Recombinant SARS-CoV-2 (2019-nCoV) Envelope Protein (N-His)

Specifications

Product Data
Species	SARS-CoV-2
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Met1-Val75
Tag	N-BBP&His
Buffer	Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 8.0.
Note	Recombinant SARS-CoV-2 (2019-nCoV) Envelope Protein is produced by our E.coli expression system and the target gene encoding Met1-Val75 is expressed with a BBP, 6His tag at the N-terminus.
Stability	12 months from date of despatch
Reference Data
Summary	Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.