Recombinant RABV Glycoprotein
Referência DRA244-50ug
Tamanho : 50ug
Marca : Novoprotein
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Description Recombinant RABV (strain SRV9) Glycoprotein is produced by our Mammalian expression system and the target gene encoding Lys20-Tyr459 expressed with a 6His tag at the C-terminus.
Accession AF499686.2
Known As Glycoprotein; G protein
Mol Mass 48.9 kDa
APMol Mass 58-70 kDa, reducing conditions
Formulation Description Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Purity-SDS-PAGE 
Greater than 95% as determined by reducing SDS-PAGE. (QC verified) Purity-SEC-HPLC 
Greater than 95% as determined by SEC-HPLC.(QC verified) Bioactivity-BLI 
Loaded Recombinant RABV Glycoprotein (DRA244) on HIS1K Biosensor, can bind RABV Glycoprotein Antibody (5G10) (DA111) with an affinity constant of 9.56 nM as determined in BLI assay. (Regularly tested) Storage - Reconstituted protein solution should be stored at ≤ -20°C.
- Stable for at least 24 months when stored as instructed.
Shipping The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Background Rabies virus (RABV), the etiological agent for the lethal disease of rabies, is a deadly zoonotic pathogen. The RABV glycoprotein (RABV-G) is a key factor mediating virus entry and the major target of neutralizing antibodies. RABV-G has three domains, and the basic-to-acidic pH change results in large domain re-orientations and concomitant domain-linker re-constructions, switching it from a bent hairpin conformation into an extended conformation. The antibody interacts with RABV-G mainly through its heavy chain and binds to a bipartite conformational epitope in the viral protein for neutralization. These structures provide valuable information for vaccine and drug design.