Recombinant Human IFN-α 2b Protein (E. coli)

Biological Activity

Human IFN-α2a and -α2b are allelic variants of the same gene, the IFN-α subtype is classified as an intermediate/strong ISG inducer and has strong antiviral activity against influenza A virus. Human IFN-α2b can be co-cultured with cpg oligonucleotide or imimiquimod in peripheral blood mononuclear cells (PBMCs), and induced in plasmacytoid dendritic cells. Recombinant human IFN-α2 is the only clinically approved subtype of IFN-α. Both IFN-α2a and IFN-α2b are used to treat chronic hepatitis B or C, hairy cell leukemia and other forms of cancer.

Recombinant Human Interferon Alpha-2b expressed the target gene encoding Cys24-Glu188.

Measured in antiviral assay using A549 human lung cancer cells infected with vesicular stomatitisvirus (VSV) The ED50 for this effect is 5 ng/mL.

Accession: P01563

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 17 kDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Product Citations

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  Adv Sci (Weinh). 2025 Aug 14; .

  The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation
  Recombinant Human IFN-α 2b Protein (E. coli) purchased from AbMole

Chemical Information

Form	Lyophilized powder
Solubility (25°C)	Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage	Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.