Tamanho : 10mg
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Synonyms: Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, Keoxifene
| Description | Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections. |
| In vitro | Raloxifene (10 μM and 50 μM) treated cells showed an increase in the percentage of cells with fragmented nuclei of 31 to 41 percent and 45 to 66 percent, respectively, after 12 and 24 hours of exposure. Treatment with Raloxifene (50 μM) resulted in increased autophagy activity in host cells, helping to prevent intracellular bacterial invasion and proliferation. [1] Treatment with Raloxifene((40-100 μM) prevented the dissolution of stress particles (SG) and promoted cell death during hypoxia of U251 and U3024 primary glioblastoma (GBM) cells. [4] |
| In vivo | Raloxifene (10 mg/kg) induced significant reductions of urea and creatinine, TNF-α, IL-1β and caspase-3 in renal isis-reperfusion injury mouse models, suggesting renal protection. [2] Treatment with Raloxifene (10 mg/kg) alleviates vision defects caused by initial cell injury (OBI) and may be associated with a reduction in the proinflammatory effects of microglia. [3] |
| Synonyms | Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, Keoxifene |
| Molecular Weight | 473.58 |
| Formula | C28H27NO4S |
| Cas No. | 84449-90-1 |
| Smiles | O=C(C1=CC=C(OCCN2CCCCC2)C=C1)C3=C(SC4=CC(O)=CC=C43)C=5C=CC(O)=CC5 |
| Relative Density. | 1.289 g/cm3 |
| Storage | Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 29.41 mg/mL (62.1 mM), Sonication is recommended.  Ethanol: 9 mg/mL (19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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