Rabbit anti Shaker (Biotinylated) Polyclonal Antibody
Specifications
Product Data
Application
WB
Recommended Dilution
WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity
Drosophila, Human
Antibody Host
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
A synthetic peptide derived from N-terminus of Shaker protein.
Buffer
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification
The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation
Biotin
Storage
Store at -20°C as received.
Stability
Stable for 12 months from date of receipt.
Shipping
Blue Ice
Predicted Protein Size
~73 kDa
Background
The assemblage of specific ion channels and receptors at synaptic sites is crucial for signaling between pre- and post-synaptic cells. DLG (Drosophila discs-large gene) is co-localized with Shaker K1 channels, which are clustered at glutamatergic synapses. DLG-Shaker interactions are required in vivo for shaker clustering at the neuromuscular junction. The channel protein Shaker which is properly synthesized, glycosylated, folded, assembled and delivered to the plasma membrane is very important for the potassium channel function.
