Tamanho : 100mg
Telefone : +1 850 650 7790
Synonyms: Serine glycerophosphatides, Phospholipids, phosphatidylserines
| Description | Phosphatidylserine is a phospholipid naturally present in mammals, exhibiting anti-inflammatory and anti-atherosclerotic effects. It activates PKC, neutral sphingolipidase, C-raf-1 protein kinase, and other cofactors involved in multiple signaling pathway activations. |
| In vitro | Phosphatidylserine suppresses inflammation in tissues by inducing TGF-β secretion, thereby avoiding immune response activation through regulatory T cell production [4]. MS049 (0.1–10 μM; 20 h) concentration-dependently reduced H3R2me2a labeling in HEK293 cells [1]. |
| In vivo | Phosphatidylserine (0.5 mg liposome; single dose; subcutaneous injection) forms liposomes with PC and cholesterol in a 30:30:40 molar ratio. These liposomes suppress in vivo immune responses by binding to and enhancing activation of phosphatidylserine receptors [4]. |
| Synonyms | Serine glycerophosphatides, Phospholipids, phosphatidylserines |
| Molecular Weight | 788.1 |
| Formula | C42H78NO10P (for oleoyl) |
| Cas No. | 1446756-47-3 |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Chloroform: Soluble, Sonication is recommended. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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