Tamanho : 1mg
| Product Data | |
| Clone Name | Nivolumab (clone: 5C4.B8) |
|---|---|
| Application | Animal Model, ELISA, FC |
| Recommended Dilution | Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator. |
| Reactivity | Human |
| Antibody Host | Mammalian Cells |
| Isotype | IgG4 |
| Clonality | Monoclonal |
| Immunogen | Recombinant human PD-1-Fc protein |
| Buffer | 0.2 μm sterile-filtered, 1 x PBS, pH 7.4 |
| Concentration | Lot-dependent |
| Purity | >95% by reducing SDS-PAGE |
| Exotoxin | < 1 EU per 1 mg of the protein by the LAL method (In vivo grade) |
| Purification | Protein A or G purification |
| Conjugation | Unconjugated |
| Stability | 12 months from date of receipt when stored at -20 to -70°C or 1 month from date of receipt when stored at 2 to 8°C |
| Shipping | Blue Ice |
| Predicted Protein Size | ~150 kDa |
| Gene Name | programmed cell death 1 |
| Database Link | |
| Background | Nivolumab is a humanized IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation S228P for additional stability and reduced variability. Nivolumab Biosimilar uses the same protein sequences as the therapeutic antibody nivolumab. |
| Synonyms | CD279; hPD-1; hPD-l; PD1; SLEB2 |
| Reference Data | |
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