Ostarine (GTx-024)

Biological Activity

Ostarine (MK-2866) is a selective androgen receptor modulator (SARM) with anabolic activity. Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio remaining in the low risk category. Ostarine exhibits significantly androgenic and anabolic activity by stimulating the growth of prostate, seminal vesicles, and levator ani muscle when administered in castrated male rats. Ostarine is more potent than other cyano/nitro group-substituted SARMs. Ostarine exhibits the highest in vivo androgenic and anabolic activity of any AR nonsteroidal agonist examined to date, with ED50 values of 0.12, 0.39 and 0.03 mg/day in prostate, seminal vesicles, and levator ani muscle, respectively. Ostarine (MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk catergory.

Product Citations

• 

  Farmacia. 2019 May 4;Vol. 67, 5.

  LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHODS FOR THE DETERMINATION OF ANDARINE AND OSTARINE IN RAT SERUM AFTER PROTEIN PRECIPITATION
  Ostarine (MK-2866) purchased from AbMole

Chemical Information

Molecular Weight	389.33
Formula	C19H14F3N3O3
CAS Number	841205-47-8
Solubility (25°C)	DMSO 80 mg/mL Ethanol 40 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Zhang X, et al. Expert Opin Ther Pat. Recent advances in the development of selective androgen receptor modulators.

[2] Mohler ML, et al. J Med Chem. Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.