Tamanho : 100mg
Telefone : +1 850 650 7790
Synonyms: Pimaricin
| Description | Natamycin (Pimaricin) is a Polyene Antimicrobial. |
| In vivo | Under conditions where growth is inhibited, Natamycin does not affect the permeability of yeast cell membranes. Natamycin impedes the initiation phase of vacuole fusion, preventing the joining of separate vacuoles without damaging the barrier function of the vacuolar membrane. It disrupts vacuole morphology within the yeast cells, resulting in the formation of numerous smaller vacuole structures. Natamycin specifically binds to ergosterol on model membranes. It exhibits a lower minimum inhibitory concentration (MIC) for dematiaceous fungi and species of Curvularia. The solubility and stability of Natamycin in aqueous solutions are enhanced through the formation of a complex with γ-cyclodextrin, which also reduces drug side effects without compromising antifungal activity. The MIC90 of both Natamycin and its complex with Natamycin-γ cyclodextrin (Natamycin-γ CyD) is below 0.0313 mg/ml, indicating that γ CyD significantly enhances the antifungal activity of Natamycin, thus affirming the clinical utility of the Natamycin-gamma CyD complex. |
| Synonyms | Pimaricin |
| Molecular Weight | 665.73 |
| Formula | C33H47NO13 |
| Cas No. | 7681-93-8 |
| Smiles | 11[C@@]12C[C@H](O)C[C@]3(O)C[C@H](O)[C@@H](C(O)=O)[C@](11)(C[C@@H](O[C@]4(11)O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O)\C=C\C=C\C=C\C=C\C[C@@H](C)OC(=O)\C=C\[C@@]1(11)O2)O3 |
| Relative Density. | 1.0 g/mL at 20°C(lit.) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 1 mg/mL (1.5 mM), Sonication is recommended.  | ||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.5 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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