Naproxen (sodium) [26159-34-2]
Referência HY-15030A-10g
Tamanho : 10g
Marca : MedChemExpress
Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
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Naproxen sodium Chemical Structure
CAS No. : 26159-34-2
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Other Forms of Naproxen sodium:
- (±)-Naproxen In-stock
- Naproxen In-stock
- Naproxen etemesil In-stock
Description |
Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. |
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IC50 & Target[1] |
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In Vitro |
Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
252.24 |
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Formule |
C14H13NaO3 |
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CAS No. |
26159-34-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C[C@H](C(O[Na])=O)C1=CC2=CC=C(OC)C=C2C=C1 |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvant et solubilité |
In Vitro:
H2O : 75 mg/mL (297.34 mM; Need ultrasonic and warming) DMSO : 5 mg/mL (19.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation |
Purity: 99.87% |
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Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 3.9645 mL | 19.8224 mL | 39.6448 mL | 99.1120 mL |
5 mM | 0.7929 mL | 3.9645 mL | 7.9290 mL | 19.8224 mL | |
10 mM | 0.3964 mL | 1.9822 mL | 3.9645 mL | 9.9112 mL | |
15 mM | 0.2643 mL | 1.3215 mL | 2.6430 mL | 6.6075 mL | |
H2O | 20 mM | 0.1982 mL | 0.9911 mL | 1.9822 mL | 4.9556 mL |
25 mM | 0.1586 mL | 0.7929 mL | 1.5858 mL | 3.9645 mL | |
30 mM | 0.1321 mL | 0.6607 mL | 1.3215 mL | 3.3037 mL | |
40 mM | 0.0991 mL | 0.4956 mL | 0.9911 mL | 2.4778 mL | |
50 mM | 0.0793 mL | 0.3964 mL | 0.7929 mL | 1.9822 mL | |
60 mM | 0.0661 mL | 0.3304 mL | 0.6607 mL | 1.6519 mL | |
80 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2389 mL | |
100 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9911 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.