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> N Cadherin Protein, Human, Recombinant (His & hFc)

N Cadherin Protein, Human, Recombinant (His & hFc)

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Referência NB-64-58762-20ug

Tamanho : 20ug

Marca : Neo Biotech

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N Cadherin Protein, Human, Recombinant (His & hFc)

(Synonyms: NCAD, CDw325, CDHN, CD325, cadherin 2, type 1, N-cadherin (neuronal)) Copy Product Info

Synonyms: NCAD, CDw325, CDHN, CD325, cadherin 2, type 1, N-cadherin (neuronal)

Catalog No. TMPY-03692 Copy Product Info
N Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is A0A024RC42.
Other Forms of N Cadherin Protein, Human, Recombinant (His & hFc):
N Cadherin Protein, Human, Recombinant (hFc)
CHRNB3 Protein, Human, Recombinant (His)
N Cadherin Protein, Human, Recombinant (His)
N Cadherin Protein, Mouse, Recombinant
CHRNB3 Protein, Human, Recombinant (hFc)
CHRNA5 Protein, Human, Recombinant (His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
N Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is A0A024RC42.
Species
Human
Expression System
HEK293 Cells
TagHis, hFc
Accession NumberP19022
ConstructionA DNA sequence encoding the human CDH2 (NP_001783.2) (Met 1-Ala 724) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. Predicted N terminal: Asp 160
Protein Purity
> 70 % as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing a 0.2 μm filtered solution in Tris and NaCl, pH 7.4, with Tween, Glycerol, and trehalose as protectants. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
SynonymsNCAD, CDw325, CDHN, CD325, cadherin 2, type 1, N-cadherin (neuronal)
Research Background
Cadherins are calcium-dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass transmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.
Chemical Properties
Molecular Weight35.2 kDa (predicted); 114 and 119 kDa (reducing condition, due to glycosylation)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

neuronalCD-325CD 325cadherin 2, type 1, N-cadherin
Related Tags: N Cadherin Protein, Human, Recombinant (His & hFc) chemical structure | N Cadherin Protein, Human, Recombinant (His & hFc) molecular weight