Monoclonal Mouse anti-Rat CD71 / Transferrin Receptor Antibody (clone OX-26, Low Endotoxin, IHC, IF, WB)
Referência LS-C43741-0.5
Tamanho : 0.5mg
Marca : LSBio
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Research Use Only
Monoclonal Mouse anti-Rat CD71 / Transferrin Receptor Antibody (clone OX-26, Low Endotoxin, IHC, IF, WB)
Catalog No. LS-C43741-0.5
- AntibodyMouse Monoclonal
- ApplicationsFlow Cytometry, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Western Blot
- ReactivityRat
- FormatLiquid
Overview
- Description
- Transferrin Receptor antibody LS-C43741 is an unconjugated mouse monoclonal antibody to rat Transferrin Receptor (CD71). Validated for Flow, IF, IHC and WB.
- Application
- FC, IF, IHC, IHC-F, IHC-P, WB
- Reactivity
- Rt
- Intended Use
- RUO
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- CD71 | TFR1 | TFRC | TRFR | TFR | TR | CD71 antigen | p90 | T9 | Transferrin receptor | Transferrin receptor protein 1
- Recommended Dilution: FC
- 1:10 - 1:100
- UniProt Number
- P02786
- NCBI GenBank
- NM_003234, NP_003225.2
- SwissProt
- P02786
Target
- Target
- Rat CD71 / Transferrin Receptor
- Antigen Species
- Rt
- Epitope
- Recognizes rat CD71, also known as transferrin receptor, a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Clone 0X-26 also binds to a number of non-dividing normal tissues. The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialized proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimer's's, Parkinson's, Huntington's and Multiple Sclerosis. Is reported as suitable for use in immunoelectron microscopy. OX-26 detects a band of ~95kD in Western blotting under reducing conditions and ~195kD under non-reducing conditions reflecting it's homodimeric structure.
- Gene Name
- TFRC
Antibody
- Host Species
- Ms
- Clonality
- Monoclonal
- Clone
- OX-26
- Isotype
- IgG2a
Immunogen
- Immunogen
- PHA activated rat lymphocytes
- Immunogen Type
- Cell
Format
- Conjugate/Label
- Unconj
- Format
- Liquid
- Formulation
- PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Prot G
Storage & Handling
- Storage Conditions
- Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS