MMAF [745017-94-1]

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Referência NB-64-20920-5mg

Tamanho : 5mg

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Telefone : +1 850 650 7790

Marca : Neo Biotech

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Contactar o distribuidor local :

Telefone : +1 850 650 7790

MMAF (Synonyms: MonoMethyl auristatin F)

Catalog No. T3256 Copy Product Info

Purity: 99.88%

MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.

MMAF

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Synonyms MonoMethyl auristatin F

MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.

Cas No. 745017-94-1

Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
Targets&IC50	H3397 cells:105 nM.
In vitro	MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF display pronounced activities. On a molar basis, the cAC10-L1-MMAF4 is an average of over 2200-fold more potent than free MMAF and is active on all the CD30-positive cell lines tested[1].
In vivo	The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively[1].
Cell Research	Cells are treated with serial dilutions of test molecules and incubated 4-6 days depending on cell line. Assessment of cellular growth and data reduction to generate IC50 values is done using Alamar Blue dye reduction assay[2].
Synonyms	MonoMethyl auristatin F

Chemical Properties

Molecular Weight	731.96
Formula	C₃₉H₆₅N₅O₈
Cas No.	745017-94-1
Smiles	CC[C@H](C)C([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C
Relative Density.	1.116 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (341.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3662 mL	6.8310 mL	13.6619 mL	68.3097 mL
5 mM	0.2732 mL	1.3662 mL	2.7324 mL	13.6619 mL
10 mM	0.1366 mL	0.6831 mL	1.3662 mL	6.8310 mL
20 mM	0.0683 mL	0.3415 mL	0.6831 mL	3.4155 mL
50 mM	0.0273 mL	0.1366 mL	0.2732 mL	1.3662 mL
100 mM	0.0137 mL	0.0683 mL	0.1366 mL	0.6831 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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