Tamanho : 1g
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Synonyms: γ-L-Glutamyl-L-cysteinyl-glycine, Tathion, Isethion, GSH, Glutathione, Glutathion
| Description | L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals. L-Glutathione reduced is a cofactor for certain enzymes and is involved in the rearrangement of protein disulfide bonds and the reduction of peroxides. |
| Targets & IC50 | KB-V1 cells:> 20 mM, Glyoxalase I:18 mM (Ki), KB 3-1 cells:> 20 mM |
| In vitro | METHODS: NSCs cells were treated with L-Glutathione reduced (0.5 mM) and sevoflurane (3%) for 24 h. Apoptosis was detected using TUNEL staining. RESULTS: Supplementation with reduced L-Glutathione reduced the effect of sevoflurane on apoptosis of NSCs. [1] |
| In vivo | METHODS: To study in vivo activity, L-Glutathione reduced (100 mg/kg) was administered orally to mice and GSH concentrations were measured in plasma at 30, 45, and 60 min, and in the liver, kidneys, heart, lungs, brain, small intestine, and skin 1 h later. RESULTS: Within 30 min of oral L-Glutathione reduced administration, plasma GSH concentrations increased from 30 µM to 75 µM, consistent with a rapid flow of GSH from the intestinal lumen to the plasma. Under these conditions of GSH sufficiency, GSH concentrations in most tissues did not exceed control values over the same time course, with the exception of lung. [2] |
| Synonyms | γ-L-Glutamyl-L-cysteinyl-glycine, Tathion, Isethion, GSH, Glutathione, Glutathion |
| Molecular Weight | 307.32 |
| Formula | C10H17N3O6S |
| Cas No. | 70-18-8 |
| Smiles | NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O |
| Relative Density. | 1.441 g/cm3 |
| Storage | Keep away from direct sunlight,The compound is unstable in solution. Please use soon Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble, The compound is unstable in solution. Please use soon. H2O: 153.7 mg/mL (500.13 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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