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L-Alanine [56-41-7]

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Referência NB-64-46424-500mg

Tamanho : 500mg

Contactar o distribuidor local :

Telefone : +1 850 650 7790

Marca : Neo Biotech

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L-Alanine

(Synonyms: L-2-Aminopropionic acid, alanine) Copy Product Info

Synonyms: L-2-Aminopropionic acid, alanine

Catalog No. TJO2729 Copy Product Info

Purity: 99.96%

L-Alanine (L-2-Aminopropionic acid) is an Amino Acid. The chemical classification of alanine is Amino Acids. Alanine is a small non-essential amino acid in humans, Alanine is one of the most widely used for protein construction and is involved in the metabolism of tryptophan and vitamin pyridoxine.

Cas No. 56-41-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White

Product Information

L-Alanine AI Summary

L-Alanine has been tested for various biological activities across different assays. It activates carbonic anhydrase isozymes with KA values of 54.0 µM (hCA I), 150.0 µM (hCA II), and 66.0 µM (bCA IV). It shows bioactivity on Alanine racemase from *Pseudomonas aeruginosa* with a Km value of 14.2 mM, and inhibits the N-methyl-D-aspartate glutamate receptor 1 in rats with IC50 values of 78.0 µM and 198.0 µM for different conditions. Additionally, it inhibits human Tyrosyl-DNA Phosphodiesterase (TDP1) and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with potencies of 2.5 µM and 354.8 nM respectively. It also inhibits human PAT1-mediated L-[3H]proline uptake in Caco2 cells with a Ki value of 2.8 mM. The compound promotes insulin release in rat BRIN-BD11 cells at 10 mM concentration, and inhibits ASCT2 mediated [3H]-D-serine uptake in rat hippocampal astrocytes by 25% at 1 mM concentration. It shows antiviral activity against SARS-CoV-2 in both Caco-2 and VERO-6 cells, with marginal inhibition rates. Additionally, it displays inhibitory activity against SARS-CoV-2 3CL-Pro protease and less than 50% inhibition in binding assays for FIBCD1 and acetylated BSA. L-Alanine also exhibits substrate activity at *Escherichia coli* B alanine racemase (Vmax of 6360 /min, Km of 1.3 mM) and HDAC6 inhibition varying from -21.28% to -3.75% depending on the peptide substrate. Despite this, it shows limited overall bioactivity as the AC50 values in all assays exceed 30.0 µM, suggesting minimal impact on the tested biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Alanine (L-2-Aminopropionic acid) is an Amino Acid. The chemical classification of alanine is Amino Acids. Alanine is a small non-essential amino acid in humans, Alanine is one of the most widely used for protein construction and is involved in the metabolism of tryptophan and vitamin pyridoxine.
Synonyms	L-2-Aminopropionic acid, alanine

Chemical Properties

Molecular Weight	89.0932
Formula	C₃H₇NO₂
Cas No.	56-41-7
Smiles	C[C@H](N)C(O)=O
Relative Density.	1.432 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 71.43 mg/mL (801.74 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	11.2242 mL	56.1210 mL	112.2420 mL	561.2101 mL
5 mM	2.2448 mL	11.2242 mL	22.4484 mL	112.2420 mL
10 mM	1.1224 mL	5.6121 mL	11.2242 mL	56.1210 mL
20 mM	0.5612 mL	2.8061 mL	5.6121 mL	28.0605 mL
50 mM	0.2245 mL	1.1224 mL	2.2448 mL	11.2242 mL
100 mM	0.1122 mL	0.5612 mL	1.1224 mL	5.6121 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

L-AlanineLAlanineL AlanineInhibitorinhibitEndogenousMetaboliteEndogenous Metabolite

Related Tags: L-Alanine chemical structure | L-Alanine formula | L-Alanine molecular weight

L-Alanine [56-41-7]

Referência NB-64-46424-500mg

Contactar o distribuidor local :

Marca : Neo Biotech

Contactar o distribuidor local :

L-Alanine

Product Information

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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