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> K-8012 [1346513-17-4]

K-8012 [1346513-17-4]

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Referência NB-64-13498-1mg

Tamanho : 1mg

Marca : Neo Biotech

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K-8012 (Synonyms: K8012, K 8012)

Catalog No. T24240 Copy Product Info
Purity: 99.72%
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.

K-8012

Copy Product Info
Synonyms K8012, K 8012

K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.

K-8012
Cas No. 1346513-17-4
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Batch Information
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Purity:99.72%
Appearance:Solid
Color:Orange
Contact us for more batch information

Resource Download
COA HNMR LCMS

Product Introduction
K-8012 AI Summary
K-8012 exhibits a binding affinity to the human GST-tagged RXRalpha ligand binding domain. This was specifically evaluated through the inhibition of 9-cis-RA-induced coactivator recruitment using a TR-FRET assay, which yielded an IC50 value of 10,000 nM for the compound..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
SynonymsK8012, K 8012
Chemical Properties
Molecular Weight374.45
FormulaC23H23FN4
Cas No.1346513-17-4
SmilesC(=C/1\C=2C(C(CCC=3NN=NN3)=C1C)=CC(F)=CC2)\C4=CC=C(C(C)C)C=C4
Relative Density.1.223 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (160.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6706 mL13.3529 mL26.7058 mL133.5292 mL
5 mM0.5341 mL2.6706 mL5.3412 mL26.7058 mL
10 mM0.2671 mL1.3353 mL2.6706 mL13.3529 mL
20 mM0.1335 mL0.6676 mL1.3353 mL6.6765 mL
50 mM0.0534 mL0.2671 mL0.5341 mL2.6706 mL
100 mM0.0267 mL0.1335 mL0.2671 mL1.3353 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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