Interferon alpha 2/IFNA2 Protein, Human, Recombinant

1.Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The ED50 for this effect is typically 0.6-4.2 pg/mL. 2.Loaded IFNAR2 Protein, Cynomolgus, Recombinant (His) (Cat#TMPY-00139) on NTA Biosensor, can bind Interferon alpha 2/IFNA2 Protein, Human, Recombinant (Cat#TMPY-00265) with an affinity constant of 23.6 nM as determined in BLI assay (Sartorius Octet RED384).

Interferon alpha 2/IFNA2 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 19.3 kDa and the accession number is P01563.1.

Human

P. pastoris (Yeast)

≥ 90 % as determined by SDS-PAGE.

IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-α genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.