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> Insulin (human) [11061-68-0]

Insulin (human) [11061-68-0]

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Referência HY-P0035-100mg

Tamanho : 100mg

Marca : MedChemExpress

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Description

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus[1][2].

In Vitro

The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region[1]. Human insulin is commonly used to treat type 2 diabetes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Insulin (human) Related Antibodies
In Vivo

Insulin (human) (0.75 U/kg; ip; once) can significantly reduce blood glucose levels in 15 minutes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Slc35d3-Flox mice and Slc35d3-wild type mice injected with 100 mg/mLl D-Glucose (HY-B0389)[1]
Dosage: 0.75 U/kg
Administration: ip; once
Result: Significantly lowers blood glucose levels.
Masse moléculaire

5807.57

Formule

C257H383N65O77S6
CAS No.
Appearance

Solid

Color

White to off-white

Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvant et solubilité
In Vitro: 

H2O : 10 mg/mL (1.72 mM; ultrasonic and adjust pH to 2 with HCl)

1 M Acetic acid : ≥ 10 mg/mL (1.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1722 mL 0.8609 mL 1.7219 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    Insulin(human)solution in dilute hydrochloric acid(pH:2~3)is diluted with PBS.(clear)

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

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