ELISA. Western Blot: Detects a band of approximately 29kDa in HD-11 cell lysates transfected with chIL-1. Functional Assays.
Reactivity
Chicken
Antibody Host
Rabbit
Clonality
Polyclonal
Immunogen
Recombinaint Chicken IL-1B
Specificity
This antibody recognizes Chicken Interleukin 1 beta (chIL-1beta), which shares homology with Mammalian IL-1 beta. Other species not tested. This antibody neutralizes IL-1 beta (Ref.1-2).
IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression. Studies using chicken models have indicated physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica.
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