ICAM1 Antibody
Referência OAEE00915
Tamanho : 100tests(T100)
Marca : Aviva Systems Biology
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| Datasheets/Manuals | Printable datasheet for ICAM1 Antibody |
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| Predicted Species Reactivity | Human |
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| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | 1H4 |
| Isotype | IgG2b |
| Host | Mouse |
| Conjugation | PerCP |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | Raji cells and spleen cells fused with NS1 cells |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 10 ul / test |
| Specificity | The antibody 1H4 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation. |
| Formulation | PerCP |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Williams DT, Chaudhry Y, Goodfellow IG, Lea S, Evans DJ.: Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites. J Gen Virol. 2004 Mar;85(Pt 3):731-8. Springer TA.: Adhesion receptors of the immune system.Nature. 1990 Aug 2;346(6283):425-34. Ockenhouse CF, Betageri R, Springer TA, Staunton DE.: Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus.Cell. 1992 Jan 10;68(1):63-9. Erratum in: Cell 1992 Mar 6;68(5):following 994. Boyd AW, Dunn SM, Fecondo JV, Culvenor JG, Duhrsen U, Burns GF, Wawryk SO.: Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation. Blood. 1989 May 15;73(7):1896-903. Boyd AW, Wawryk SO, Burns GF, Fecondo JV.: Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cellcontact-mediated immune mechanisms. Proc Natl Acad Sci U S A. 1988 May;85(9):3095-9. |
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| Gene Symbol | ICAM1 |
| Gene Full Name | intercellular adhesion molecule 1 |
| Alias Symbols | BB2, CD54, cell surface glycoprotein P3.58, epididymis secretory sperm binding protein, ICAM-1, intercellular adhesion molecule 1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, major group rhinovirus receptor, P3.58. |
| NCBI Gene Id | 3383 |
| Protein Name | Intercellular adhesion molecule 1 |
| Description of Target | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
| Uniprot ID | P05362 |
| Protein Accession # | NP_000192.2 |
| Nucleotide Accession # | NM_000201.2 |
