1. Results show that VGF is epigenetically modified in human non-small-cell lung cancer (NSCLC) tissues if compared to tumor-free lung tissues, which results in an increased transcription and protein expression.
2. results suggest VGF enhances dendritic maturation and that these effects can be altered by common SNPs in the VGF gene
3. We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity.
4. Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels.
5. Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma.
6. Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls.
7. Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element
8. NERPs may be potent endogenous suppressors of glucose-dependent insulin secretion.
9. DISC1 knockdown leads to a reduction of VGF in neurons.
10. Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance.
11. We conclude that VGF contributes to survival and function of peripheral T cells
12. Among the 19 genes tested, VGF was found to be completely methylated in several Urothelial Cell Carcinoma cell lines
13. The expression of NPY and VGF was increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius in the brains of type-II diabetic patients.
14. [review] The vgf gene is induced in vivo by neurotrophins including nerve growth factor (NGF), brain derived growth factor (BDNF) and glial derived growth actor (GDNF), by synaptic activity and by homeostatic and other stimuli.
15. VGF is regulated by SOD1 and plays a critical role in motor neuron survival
16. localization of neuroendocrine regulatory peptide-1 and-2 (NERP-1 and NERP-2); results suggest that neuroendocrine NERP-1 and NERP-2 might function as local modulatorsin the neuroendocrine system
17. VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann's area 9 of the prefrontal cortex.
18. VGF mRNA levels were significantly reduced in drug-free depressed patients, as compared with controls, and were modulated in response to effective antidepressant treatment.
19. Application of neurosecretory protein VGF biomarker model to current diagnostic criteria provides an objective biomarker pattern that identifies patients with amyotrophic lateral sclerosis.
20. proVGF-related peptides are present in endocrine cells early during development and adulthood and increase in hyperplasia and tumors
21. while Vgf may be a reliable biomarker of progression of muscle weakness in patients with ALS, restoration of Vgf expression in spinal cord motor neurons may therapeutically rescue spinal cord motorneurons against excitotoxic injury

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