Human [Arg3] IGF-I (Media Grade)

Human [Arg3] insulin-like Growth Factor-I (IGF-I) is a 70 amino acid analogue of IGF-I comprising the complete human IGF-I sequence with the substitution of an Arginine for the Glutamine at position 3. Human [Arg3] IGF-I is more potent than IGF-I in vitro and in vivo. This increased potency is due to reduced binding of human [Arg3] IGF-I to most of the IGF binding proteins which modify the biological actions of IGF-I. Human [Arg3] IGF-I binds to the type 1 IGF receptor with similar affinity to wild type IGF-I. This is a high quality research reagent for use in studies on cell growth, IGF receptors and IGF binding proteins.