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> Human 26S proteasome non ATPase regulatory subunit 12 (PSMD12) activation kit by CRISPRa

Human 26S proteasome non ATPase regulatory subunit 12 (PSMD12) activation kit by CRISPRa

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Human 26S proteasome non ATPase regulatory subunit 12 (PSMD12) activation kit by CRISPRa

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SKU
GA103885
PSMD12 CRISPRa kit - CRISPR gene activation of human proteasome 26S subunit, non-ATPase 12
 

Other products for "PSMD12"

Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PSMD12
Locus ID 5718
Components

GA103885G1, 26S proteasome non ATPase regulatory subunit 12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103885G2, 26S proteasome non ATPase regulatory subunit 12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103885G3, 26S proteasome non ATPase regulatory subunit 12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001316341, NM_002816, NM_174871
UniProt ID O00232
Synonyms p55; Rpn5
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2015
SKU Description Size
KN405680 PSMD12 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit

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