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> H 1152 dihydrochloride [451462-58-1]

H 1152 dihydrochloride [451462-58-1]

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Referência VD-AM-0102-5mg

Tamanho : 5mg

Marca : VDM Biochemicals

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Product Specification

  • Appearance
    :

    White to off-white solid.

  • CAS Number
    :

    451462-58-1

  • Cat.number
    :

    VD-AM-0102

  • Formula
    :

    C16H21N3O2S.2HCl

  • MW
    :

    392.34

  • Purity
    :

    ≥98%

  • Solubility
    :

    Soluble to 100 mM in H2O and to 50 mM in DMSO

  • Storage
    :

    +4°C.

  • Synonyms
    :

    Not available.

  • Size
    :

    1mg, 5mg

SKU: VD-AM-0102 Categories: Angiogenesis and Metastasis, Cancer

Description

H 1152 dihydrochloride (CAS 451462-58-1) is a Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea-pig aorta (IC50 = 190 nM) and displays proerectile effects in rats.

1. Shum et al (2003) Br.J.Pharmacol. 139 1449.
2. Teixeira et al (2005) J.Pharmacol.Exp.Ther. 315 155.
3. Tamura et al (2005) Biochim.Biophys.Acta 1754 245.