Goat anti-CB1 (isoform a) Antibody
Referência MBS422680-0,1mg
Tamanho : 0.1mg
Marca : MyBiosource
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MBS422680 (0.3ug/ml) staining of A549 (A) and NIH3T3 (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
CNR1 Antibody – Goat Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422680MBS422680 is an antibody targeting CNR1. Also known as Goat anti-CB1 (isoform a) Antibody. Reactive in Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details
Product Overview
Online Datasheet in PDFProduct Name
CB1 (CNR1), Polyclonal Antibody
Full Product Name
Goat anti-CB1 (isoform a) Antibody
Product Gene Name
anti-CNR1 antibody
Product Synonym Gene Name
CB1
Product Synonym Names
Goat Anti-CB1 (aa44-58) Antibody; CNR1; cannabinoid receptor 1 (brain); CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR; OTTHUMP00000016839; cannabinoid receptor 1; central cannabinoid receptor; CNR1 antibody; cannabinoid receptor 1 (brain) antibody; CANN6 antibody; CB-R antibody; CB1 antibody; CB1A antibody; CB1K5 antibody; CB1R antibody; CNR antibody; cannabinoid receptor 1 antibody; central cannabinoid receptor antibody; CB1 (isoform a)
Immunogen Sequence
SNDIQYEDIK GDMAS
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Preparation and Storage
Aliquot and store at -20°C. Minimize freezing and thawing.
Antibody/Peptide Pairs
CB1 peptide (MBS427507) is used for blocking the activity of CB1 antibody (MBS422680)
OMIM
114610
Immunogen
Peptide with sequence SNDIQYEDIKGDMAS-C, from the N Terminus of the protein sequence according to NP_057167.2.
Note
This antibody is expected to recognize reported isoform a (NP_057167.2) only. Reported variants represent identical protein: NP_001153731.1, NP_001153732.1, NP_057167.2, NP_001153730.1, NP_001153698.1
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-CNR1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-CNR1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 52kDa band observed in lysates of cell lines A549 and NIH3T3 (calculated MW of 52.9kDa according to Human NP_057167.2 and 52.8kDa according to Mouse NP_031752.1). Recommended concentration: 0.3-1ug/ml.
Western Blot: Approx 52kDa band observed in lysates of cell lines A549 and NIH3T3 (calculated MW of 52.9kDa according to Human NP_057167.2 and 52.8kDa according to Mouse NP_031752.1). Recommended concentration: 0.3-1ug/ml.
Other Notes
Small volumes of anti-CNR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CNR1. It may not necessarily be applicable to this product.
NCBI Official Full Name
cannabinoid receptor 1 isoform a
NCBI Official Synonym Full Names
cannabinoid receptor 1 (brain)
NCBI Official Symbol
CNR1
NCBI Official Synonym Symbols
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
UniProt Protein Name
Cannabinoid receptor 1
UniProt Synonym Protein Names
CANN6
Protein Family
Cannabinoid receptor
UniProt Gene Name
CNR1
UniProt Synonym Gene Names
CNR; CB-R; CB1
UniProt Entry Name
CNR1_HUMAN
NCBI Protein Information
cannabinoid receptor 1
NCBI Summary for CNR1
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Show more UniProt Comments for CNR1
CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q14-q15
Cellular Component: axon; growth cone; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; plasma membrane
Molecular Function: cannabinoid receptor activity; drug binding
Biological Process: aging; axonal fasciculation; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; maternal process involved in pregnancy; memory; negative regulation of action potential; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of fatty acid beta-oxidation; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of apoptosis; positive regulation of blood pressure; positive regulation of fever; regulation of insulin secretion; regulation of synaptic transmission, GABAergic; regulation of synaptic transmission, glutamatergic; response to cocaine; response to ethanol; response to lipopolysaccharide; response to morphine; response to nicotine; response to nutrient; sensory perception of pain; spermatogenesis
Show more Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q14-q15
Cellular Component: axon; growth cone; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; plasma membrane
Molecular Function: cannabinoid receptor activity; drug binding
Biological Process: aging; axonal fasciculation; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; maternal process involved in pregnancy; memory; negative regulation of action potential; negative regulation of blood pressure; negative regulation of dopamine secretion; negative regulation of fatty acid beta-oxidation; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of apoptosis; positive regulation of blood pressure; positive regulation of fever; regulation of insulin secretion; regulation of synaptic transmission, GABAergic; regulation of synaptic transmission, glutamatergic; response to cocaine; response to ethanol; response to lipopolysaccharide; response to morphine; response to nicotine; response to nutrient; sensory perception of pain; spermatogenesis
Research Articles on CNR1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CNR1 antibody
| Reference Product | PubMed Publications |
|---|---|
| DRD2 antibody | >16 publications with CNR1 and DRD2 |
| NPY antibody | >9 publications with CNR1 and NPY |
| GPR55 antibody | >9 publications with CNR1 and GPR55 |
| TRPV1 antibody | >9 publications with CNR1 and TRPV1 |
| POMC antibody | >4 publications with CNR1 and POMC |
| SST antibody | >1 publications with CNR1 and SST |
| GPR18 antibody | >1 publications with CNR1 and GPR18 |
| VR1 antibody | >1 publications with CNR1 and VR1 |
Pathways associated with anti-CNR1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| BDNF Signaling Pathway antibodies | BDNF Signaling Pathway Diagram |
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| GPCRs, Class A Rhodopsin-like Pathway antibodies | GPCRs, Class A Rhodopsin-like Pathway Diagram |
| N-cadherin Signaling Events Pathway antibodies | N-cadherin Signaling Events Pathway Diagram |
| Neuroactive Ligand-receptor Interaction Pathway antibodies | Neuroactive Ligand-receptor Interaction Pathway Diagram |
| Neuroactive Ligand-receptor Interaction Pathway antibodies | Neuroactive Ligand-receptor Interaction Pathway Diagram |
| Rap1 Signaling Pathway antibodies | Rap1 Signaling Pathway Diagram |
Diseases associated with anti-CNR1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Obesity Antibodies | >71 publications with CNR1 and Obesity |
| Substance-Related Disorders Antibodies | >57 publications with CNR1 and Substance-Related Disorders |
| Schizophrenia Antibodies | >44 publications with CNR1 and Schizophrenia |
| Disease Models, Animal Antibodies | >42 publications with CNR1 and Disease Models, Animal |
| Brain Diseases Antibodies | >31 publications with CNR1 and Brain Diseases |
| Pain Antibodies | >31 publications with CNR1 and Pain |
| Inflammation Antibodies | >24 publications with CNR1 and Inflammation |
| Weight Gain Antibodies | >22 publications with CNR1 and Weight Gain |
| Weight Loss Antibodies | >22 publications with CNR1 and Weight Loss |
| Marijuana Abuse Antibodies | >21 publications with CNR1 and Marijuana Abuse |
Organs/Tissues associated with anti-CNR1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >181 publications with CNR1 and Brain |
| Liver Antibodies | >28 publications with CNR1 and Liver |
| Muscle Antibodies | >15 publications with CNR1 and Muscle |
| Vascular Antibodies | >12 publications with CNR1 and Vascular |
| Eye Antibodies | >10 publications with CNR1 and Eye |
| Embryonic Tissue Antibodies | >6 publications with CNR1 and Embryonic Tissue |
| Pancreas Antibodies | >6 publications with CNR1 and Pancreas |
| Lung Antibodies | >5 publications with CNR1 and Lung |
| Testis Antibodies | >4 publications with CNR1 and Testis |
| Uterus Antibodies | >3 publications with CNR1 and Uterus |
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