Ganglioside GM2, Asialo [35960-33-9]

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Referência 451084-250ug

Tamanho : 250ug

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Telefone : +1 850 650 7790

Marca : US Biological

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Contactar o distribuidor local :

Telefone : +1 850 650 7790

Ganglioside GM2, Asialo [35960-33-9]

451084 Ganglioside GM2, Asialo

Grade

Highly Purified

Shipping Temp

Storage Temp

-20°C

Asialylated glycosphingolipid, which is also known as asialo-GM2 ganglioside. This compound accumulates in the cells of individuals with the Sandhoff disease, a lysosomal storage disorder, where β-hexosaminase is dysfunctional and unable to break down GA2 ganglioside to lactosylceramide (LacCer).

Synonyms:
CeCeramide trihexoside, Gangliotriosylceramide, Asialoganglioside-GM2; GgOse3Cer; b-GalNAc-(1→4)-b-Gal-(1→4)-b-Glc-(1→1')-Cer; 1-O-[O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide

CAS No:
35960-33-9

Molecular Formula:
C56H104N2O18

Molecular Weight:
1093.43

Appearance:
White to off-white powder

Purity:
≥95%

Identity (1H NMR):
Conforms to structure

Solubility:
Chloroform, Methanol

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Form

White to off-white powder

Purity

≥95%

References

1. Baek, R.C., Martin, D.R., Cox, N.R., et al. Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease. Lipids 44(3), 197-205 (2009).|2. Krivan, H.C., Ginsburg, V., and Roberts, D.D. Pseudomonas aeruginosa and Pseudomonas cepacia isolated from cystic fibrosis patients bind specifically to gangliotetraosylceramide (asialo GM1) and gangliotriaosylceramide (asialo GM2). Arch. Biochem. Biophys. 260(1), 493-496 (1988).