G-418 disulfate [108321-42-2]
Referência NB-64-35114-1g
Tamanho : 1g
Marca : Neo Biotech
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Telefone : +1 850 650 7790
G-418 disulfate (Synonyms: Geneticin sulfate, Geneticin, G418 Sulfate, Antibiotic G-418 sulfate)
Catalog No. T6512 Copy Product Info
Purity: 99.9%
G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.
G-418 disulfate
Copy Product InfoSynonyms Geneticin sulfate, Geneticin, G418 Sulfate, Antibiotic G-418 sulfate
G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.
Cas No. 108321-42-2
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation. |
| Targets&IC50 | 3T3 cells:213 µg/mL, BHK-21 cells:69 µg/mL, CHO-K1 cells:311 µg/mL, HeLa cells:483 µg/mL |
| In vitro | Continuous administration of G418 at doses ranging from 40 to 80 mg/kg for three consecutive days is sufficient to eradicate all untransfected Brucella bacterium parasites in infected mice. |
| In vivo | At concentrations ranging from 1 to 300 micrograms/ml, G418 inhibits a variety of prokaryotic and eukaryotic organisms. Typically, concentrations of 5 mg/L or lower are effective against bacteria and algae, while a concentration of 400 mg/L is used for the selection of mammalian cells, and a maintenance concentration for mammalian cells is set at 200 mg/L. |
| Synonyms | Geneticin sulfate, Geneticin, G418 Sulfate, Antibiotic G-418 sulfate |
| Molecular Weight | 692.71 |
| Formula | C20H40N4O10·2H2O4S |
| Cas No. | 108321-42-2 |
| Smiles | OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 252 mg/mL (363.79 mM), Sonication is recommended.  DMSO: Insoluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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