FITC-Dextran (MW 4000) [60842-46-8]

Biological Activity

FITC-Dextran is a marker consisting of coupling fluorescein-isothiocyanate to dextran. FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.

Product Citations

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  Phytomedicine. 2025 Oct 10; .

  Daidzein alleviates chronic restraint stress-induced depression-like behavior by regulating neuroinflammation and synaptic plasticity via microbiota-gut-brain axis
  FITC-Dextran (MW 4000) purchased from AbMole

• 

  Aging (Albany NY). 2024 Mar 21;16(7):5905-5915.

  Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway
  FITC-Dextran (MW 4000) purchased from AbMole

Chemical Information

CAS Number	60842-46-8
Solubility (25°C)	Water ≥ 30 mg/mL
Storage	4°C, protect from light, dry, sealed

References

[1] Eriksson I, et al. Methods Mol Biol. Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells.

[2] Natarajan R, et al. Curr Protoc Neurosci. Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability.

[3] Michio Kawano, et al. J Nutr Sci . Lactobacillus gasseri SBT2055 inhibits adipose tissue inflammation and intestinal permeability in mice fed a high-fat diet

[4] Hoffmann A, et al. Transl Stroke Res. High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)-Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations.