Tamanho : 100mg
Telefone : +1 850 650 7790
Synonyms:
| Description | EBOV-IN-7 (compound 26) acts as an inhibitor against the Ebola virus EBOV, displaying an IC 50 value of 2.04 μM against pEBOV (EBOV-GP pseudotyped virus). It also obstructs the EBOV-GPcl/NPC1 interaction and exhibits inhibitory effects on cancer cells. [8] [1] |
| In vitro | EBOV-IN-7 (compound 26) exhibits a CC50 of 60 μM in HeLa cells, with low cytotoxicity in Vero cells (CC50 >100 μM) [1]. At a concentration of 50 μM, it significantly disrupts the interaction between EBOV-GPcl and NPC1, showing an IC50 of 2.04 μM against EBOV-GP-pseudotyped virus (pEBOV) [1]. For African swine fever virus (ASFV), the compound has an IC50 of 15.75 μM [1]. |
| Molecular Weight | 406.89 |
| Formula | C18H19ClN4O3S |
| Cas No. | 68207-16-9 |
| Smiles | S(C1=C(N(=O)=O)C=CC(Cl)=C1)C2=C(NNC(CN3CCCC3)=O)C=CC=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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