DNMT1 Antibody
Referência OACA09362-50UG
Tamanho : 50ug
Marca : Aviva Systems Biology
Contactar o distribuidor local :
Telefone : +1 850 650 7790
DNMT1 Antibody (OACA09362)
| Datasheets/Manuals | Printable datasheet for DNMT1 Antibody (OACA09362) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | ELISA|IF|IHC |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human DNA (cytosine-5)-methyltransferase 1 protein (1288-1632AA) |
| Purification | Protein G Purified |
| Preservative | 0.03% Proclin 300 |
| Formulation | 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purity | >95% |
| Gene Symbol | DNMT1 |
|---|---|
| Gene Full Name | DNA methyltransferase 1 |
| Alias Symbols | ADCADN, AIM, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5-)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase HsaI, DNA MTase HsaI, DNMT, HSN1E, m.HsaI, MCMT. |
| NCBI Gene Id | 1786 |
| Protein Name | DNA (cytosine-5)-methyltransferase 1 |
| Description of Target | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). |
| Uniprot ID | P26358 |
| Protein Accession # | NP_001124295 |
| Nucleotide Accession # | NM_001130823 |
