Tamanho : 50mg
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Synonyms: 2-Borneol, (endo)-Borneol, (±)-Borneol
| Description | DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an orally bioadjuvant that improves drug delivery to the brain and is commonly used as an adjuvant ingredient in TCM for the treatment of cardio-cerebral vascular diseases. |
| Targets & IC50 | 26S:157±19 μM, 20S proteasome:118.8±15.7 μM |
| In vitro | In vitro, Borneol enhances the intracellular accumulation of Rho123 and facilitates the transport of P-gp substrates across the blood-brain barrier (BBB). Additionally, it downregulates the expression of mdr1a mRNA and P-gp. Borneol activates NF-κB, and the inhibition of NF-κB with MG132 and SN50 attenuates the reduction in P-gp induced by Borneol. Treatment with 10 μg/mL and 20 μg/mL Borneol transiently increases the phosphorylation of IκB expression at 30 min post-treatment. Furthermore, Borneol treatment leads to a decrease in P-gp expression in brain microvascular endothelial cells (BMECs)[1]. |
| In vivo | Borneol significantly counteracts the process of epileptogenesis in PTZ-kindled mice. Borneol-treated animals show amelioration of biochemical alterations induced by PTZ kindling, as evidenced by decreased lipid peroxidation (LPO) and increased levels of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). The distinct neuronal damage observed in the kindled group is suppressed by Borneol. Additionally, Borneol reduces the levels of GFAP, as indicated by reduced immunostaining[3]. The pharmacokinetic traits of Borneol are significantly affected by the pathological damages of ischemia-reperfusion, and there are components in Xingnaojing that inhibit the absorption of Borneol[2]. |
| Synonyms | 2-Borneol, (endo)-Borneol, (±)-Borneol |
| Molecular Weight | 154.25 |
| Formula | C10H18O |
| Cas No. | 507-70-0 |
| Smiles | 09[C@]12CC[C@](C)([C@@H](O)C1)C2(C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (194.49 mM), Sonication is recommended. H2O: <0.1 mg/mL (Insoluble) | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.97 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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