Biological Activity

Dextran sulfate sodium salt is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. Dextran Sulfate Sodium (DSS) can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.

Product Citations

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  Phytother Res. 2026 Mar 23; .

  A Combined Colon Organoid-Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease.
  Dextran sulfate sodium salt purchased from AbMole

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  J Agric Food Chem. 2026 Apr 22;74:12087-12101.

  Ophiopogon japonicus Polysaccharides Promote Microbial Production Of Chenodeoxycholic Acid To Alleviate Ulcerative Colitis in Mice by Inhibiting the STING1
  Dextran sulfate sodium salt purchased from AbMole

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  Int Immunopharmacol. 2026 Feb 24;174:116344.

  Thrombospondin-1-mediated macrophage efferocytosis dysfunction exacerbates intestinal pathology in Hirschsprung's disease
  Dextran sulfate sodium salt purchased from AbMole

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  Cell Res. 2025 May 09; .

  DNA remnants in red blood cells enable early detection of cancer
  Dextran sulfate sodium salt purchased from AbMole

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  Gut Microbes. 2025 Sep 03;17(1):2547029.

  Gut microbiota dysbiosis affects intestinal sensitivity through epithelium-to-neuron signaling: novel insights from a colon organoid-based model to improve visceral pain therapy
  Dextran sulfate sodium salt purchased from AbMole

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  Int J Biol Macromol. 2025 Apr 30.

  Anti-colitis comparison of polysaccharides and anthocyanins extracted from black wolfberry based on microbiomics, immunofluorescence and multi-cytokines profile analysis
  Dextran sulfate sodium salt purchased from AbMole

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  Am J Chin Med. 2025 Jun 30;53(4):1207-1224.

  Celastrol Alleviates Intestinal Epithelial Permeability by Inhibiting Ferroptosis through PI3K/Akt/FOXO1/HO-1 Signaling Pathway
  Dextran sulfate sodium salt purchased from AbMole

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  J Nutr Biochem. 2025 Dec 01;149:110212.

  Astaxanthin alleviates DSS-induced ulcerative colitis in mice associated with Nrf2-mediated ferroptosis independently of gut microbiota modulation.
  Dextran sulfate sodium salt purchased from AbMole

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  Chinese Journal of Analytical Chemistry. 2025 Sep 10; .

  Evaluation of Combined Paeoniflorin and Glycyrrhizin Therapy for Ulcerative Colitis In Vitro and In Vivo
  Dextran sulfate sodium salt purchased from AbMole

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  Biomed Pharmacother. 2024 Jun 26.

  Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation
  Dextran sulfate sodium salt purchased from AbMole

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  Biomed Pharmacother. 2023 Sep;165:115273.

  Discovery of a novel small molecule with efficacy in protecting against inflammation in vitro and in vivo by enhancing macrophages activation
  Dextran sulfate sodium salt purchased from AbMole

Chemical Information

Formula	(C6H7Na3O14S3)n
CAS Number	9011-18-1
Solubility (25°C)	Water 100 mg/mL
Storage	2-8°C, sealed

References

[1] Baba M, et al. Proc Natl Acad Sci U S A. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.