DATPT [2891582-75-3]

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Referência NB-64-41586-5mg

Tamanho : 5mg

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Telefone : +1 850 650 7790

Marca : Neo Biotech

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Contactar o distribuidor local :

Telefone : +1 850 650 7790

DATPT

Catalog No. T74398 Copy Product Info

Purity: 99.93%

DATPT is a small molecule 12WLVSKF17 peptide mimetic molecule.DATPT inhibits SNX9-p47phox interactions and inhibits the production of reactive oxygen species and inflammatory cytokines.DATPT has anti-inflammatory and antimicrobial activity and acts by decreasing ATP production.DATPT is a potential compound for the treatment of sepsis.

DATPT

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Cas No. 2891582-75-3

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

DATPT AI Summary

DATPT exhibits significant anti-inflammatory properties by reducing LPS-induced TNF-alpha, NOX, and IL-6 release in human BMDM cells. It also demonstrates antibacterial efficacy against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Pharmacokinetics in mice reveal a Tmax of 0.17 hr, Cmax of 296.55 nM, AUC of 209.18 ng.hr.mL^-1, and a half-life of 1.06 hr. The compound is stable in human liver microsomes and plasma but inhibits CYP enzymes CYP3A4, CYP2CJ, and CYP2C9, while showing no inhibition on CYP2D6 and CYP1A2. Additionally, DATPT protects against sepsis in a mouse model with an activity rate of 70.0%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	495.06
Formula	C₂₄H₃₉ClN₆O₃
Cas No.	2891582-75-3
Smiles	Cl.N=1C(=NC(=NC1NCC2OCCC2)C=3C=CC(=CC3)C(C)(C)C)NCCOCCOCCN

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (161.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0200 mL	10.0998 mL	20.1996 mL	100.9979 mL
5 mM	0.4040 mL	2.0200 mL	4.0399 mL	20.1996 mL
10 mM	0.2020 mL	1.0100 mL	2.0200 mL	10.0998 mL
20 mM	0.1010 mL	0.5050 mL	1.0100 mL	5.0499 mL
50 mM	0.0404 mL	0.2020 mL	0.4040 mL	2.0200 mL
100 mM	0.0202 mL	0.1010 mL	0.2020 mL	1.0100 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.