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D-Glucose [50-99-7]

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Referência NB-64-01050-5g

Tamanho : 5g

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Telefone : +1 850 650 7790

Marca : Neo Biotech

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D-Glucose

(Synonyms: Grape sugar, Glucopyranose, Dextrose, D(+)-Glucose) Copy Product Info

Synonyms: Grape sugar, Glucopyranose, Dextrose, D(+)-Glucose

Catalog No. T0887 Copy Product Info

Purity: 99.98%

D-Glucose (Glucopyranose) is a monosaccharide, a natural glucose, a sweetener. D-Glucose is the main functional substance of living organisms, and is used as a nutrient in medicine, with diuretic, detoxification and cardiotonic effects.

Cas No. 50-99-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Color:White

Product Introduction

D-Glucose AI Summary

D-Glucose exhibits a variety of bioactivities and pharmacokinetic properties. It shows acceptor substrate specificity toward Fucosyltransferase for the galactosides of GlcNAc with beta 1,3 or beta 1,4-linkages. The compound demonstrates high catalytic efficiency with a kcat/Km ratio of 21.0 M-1 s-1 and a binding energy of 8.7 kCal mol-1. It also shows effective human permeability (Peff = 10.0) and complete intestinal absorption (Fa = 100.0%). D-Glucose inhibits glycogen phosphorylase b across several species, with varying Ki values observed: 1.7 µM to 7.4 µM in rabbits, and 1.58 µM to 7.94 µM in pigs. It also inhibits AMPKalpha activation and shows significant insulinotropic activity in rat INS-1 cells, enhancing glucose-induced insulin release. In antiviral assays, D-Glucose exhibits activity against SARS-CoV-2, with a moderate hit score in HRCE cells and some cytotoxicity inhibition in VERO-6 cells. Additionally, it demonstrates inhibitory actions on yeast alpha-glucosidase (IC50 = 2600 nM), GLUT1, GLUT2, GLUT3, and GLUT4 transporters, with varying EC50 values. Despite comprehensive testing, D-Glucose revealed no effect on spinal anesthesia and no drug-induced liver injury in human liver cells. It also showed antioxidative properties, having significant DPPH radical scavenging activity and peroxynitrite radical scavenging activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-Glucose (Glucopyranose) is a monosaccharide, a natural glucose, a sweetener. D-Glucose is the main functional substance of living organisms, and is used as a nutrient in medicine, with diuretic, detoxification and cardiotonic effects.
In vitro	METHODS: Differentiated Caco-2 cells were stimulated with D-Glucose (125-500 mM) for 5 min and serotonin levels were measured. RESULTS: Caco-2 cells released 5-hydroxytryptamine in response to D-Glucose similar to enterochromaffin cells. In response to the highest tested concentration of 500 mM D-Glucose, 5-hydroxytryptamine levels in the supernatant of Caco-2 cells increased by 81.9±25.0%. [1] METHODS: Retinal endothelial cells were treated with D-Glucose (30 mM) for 7 days and cell viability was measured by MTT assay. RESULTS: The viability of endothelial cells exposed to high glucose was significantly reduced to 76.0±2.6% of the control. [2]
In vivo	METHODS: For oral glucose tolerance test (OGTT), rats were starved for 6 h and orally administered MET (200 mg/kg) 1 h before glucose loading. Only distilled water was used as the vehicle in the control group. Wistar rats were fed 50% D-Glucose solution (4 g/kg) and GK diabetic rats were fed at 50% D-Glucose solution (1 g/kg). All blood samples were collected by tail flow 0-120 min after glucose administration and blood glucose was determined. RESULTS: Rats receiving MET had a lower apical density of SGLT1 in the jejunum, lower levels of phosphorylated PKA substrate in enterocytes, and lower PGR compared to rats treated with excipients. [3]
Synonyms	Grape sugar, Glucopyranose, Dextrose, D(+)-Glucose

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	50-99-7
Smiles	[C@H]([C@@H]([C@H](C=O)O)O)([C@@H](CO)O)O
Relative Density.	1.544g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 240 mg/mL (1332.15 mM), Sonication is recommended.

H2O: 33 mg/mL (183.17 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitGlucoseEndogenousMetaboliteEndogenous MetaboliteD-GlucoseDGlucoseD Glucose

Related Tags: D-Glucose chemical structure | D-Glucose in vivo | D-Glucose in vitro | D-Glucose formula | D-Glucose molecular weight