D-Glucose [50-99-7]

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Referência NB-64-01050-5g

Tamanho : 5g

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Telefone : +1 850 650 7790

Marca : Neo Biotech

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Contactar o distribuidor local :

Telefone : +1 850 650 7790

D-Glucose (Synonyms: Grape sugar, Glucopyranose, Dextrose, D(+)-Glucose)

Catalog No. T0887 Copy Product Info

Purity: 99.98%

D-Glucose (Glucopyranose) is a monosaccharide, a natural glucose, a sweetener. D-Glucose is the main functional substance of living organisms, and is used as a nutrient in medicine, with diuretic, detoxification and cardiotonic effects.

D-Glucose

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Synonyms Grape sugar, Glucopyranose, Dextrose, D(+)-Glucose

Cas No. 50-99-7

Batch Information

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Purity:99.98%

Color:White

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COA HNMR LCMS

Product Introduction

D-Glucose AI Summary

D-Glucose exhibits a variety of bioactivities and pharmacokinetic properties. It shows acceptor substrate specificity toward Fucosyltransferase for the galactosides of GlcNAc with beta 1,3 or beta 1,4-linkages. The compound demonstrates high catalytic efficiency with a kcat/Km ratio of 21.0 M-1 s-1 and a binding energy of 8.7 kCal mol-1. It also shows effective human permeability (Peff = 10.0) and complete intestinal absorption (Fa = 100.0%). D-Glucose inhibits glycogen phosphorylase b across several species, with varying Ki values observed: 1.7 µM to 7.4 µM in rabbits, and 1.58 µM to 7.94 µM in pigs. It also inhibits AMPKalpha activation and shows significant insulinotropic activity in rat INS-1 cells, enhancing glucose-induced insulin release. In antiviral assays, D-Glucose exhibits activity against SARS-CoV-2, with a moderate hit score in HRCE cells and some cytotoxicity inhibition in VERO-6 cells. Additionally, it demonstrates inhibitory actions on yeast alpha-glucosidase (IC50 = 2600 nM), GLUT1, GLUT2, GLUT3, and GLUT4 transporters, with varying EC50 values. Despite comprehensive testing, D-Glucose revealed no effect on spinal anesthesia and no drug-induced liver injury in human liver cells. It also showed antioxidative properties, having significant DPPH radical scavenging activity and peroxynitrite radical scavenging activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-Glucose (Glucopyranose) is a monosaccharide, a natural glucose, a sweetener. D-Glucose is the main functional substance of living organisms, and is used as a nutrient in medicine, with diuretic, detoxification and cardiotonic effects.
In vitro	METHODS: Differentiated Caco-2 cells were stimulated with D-Glucose (125-500 mM) for 5 min and serotonin levels were measured. RESULTS: Caco-2 cells released 5-hydroxytryptamine in response to D-Glucose similar to enterochromaffin cells. In response to the highest tested concentration of 500 mM D-Glucose, 5-hydroxytryptamine levels in the supernatant of Caco-2 cells increased by 81.9±25.0%. [1] METHODS: Retinal endothelial cells were treated with D-Glucose (30 mM) for 7 days and cell viability was measured by MTT assay. RESULTS: The viability of endothelial cells exposed to high glucose was significantly reduced to 76.0±2.6% of the control. [2]
In vivo	METHODS: For oral glucose tolerance test (OGTT), rats were starved for 6 h and orally administered MET (200 mg/kg) 1 h before glucose loading. Only distilled water was used as the vehicle in the control group. Wistar rats were fed 50% D-Glucose solution (4 g/kg) and GK diabetic rats were fed at 50% D-Glucose solution (1 g/kg). All blood samples were collected by tail flow 0-120 min after glucose administration and blood glucose was determined. RESULTS: Rats receiving MET had a lower apical density of SGLT1 in the jejunum, lower levels of phosphorylated PKA substrate in enterocytes, and lower PGR compared to rats treated with excipients. [3]
Synonyms	Grape sugar, Glucopyranose, Dextrose, D(+)-Glucose

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	50-99-7
Smiles	[C@H]([C@@H]([C@H](C=O)O)O)([C@@H](CO)O)O
Relative Density.	1.544g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 240 mg/mL (1332.15 mM), Sonication is recommended.

H2O: 33 mg/mL (183.17 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.