Cytokeratin 17 (K17, Keratin Type I Cytoskeletal 17, Keratin-17, KRT17, PCHC1) (AP)
Referência MBS6124096-5x0,1mL
Tamanho : 5x0.1mL
Marca : MyBiosource
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Cytokeratin 17 (K17, Keratin Type I Cytoskeletal 17, Keratin-17, KRT17, PCHC1) (AP)
Western Blot of HeLa lysate using (SPM560).
Immunohistochemistry analysis in formalin-paraffin skin stained with (SPM560).
Immunohistochemistry analysis in formalin-paraffin skin stained with (SPM560).
Cytokeratin 17 (KRT17) Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6124096Cytokeratin 17 (CK17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IFP's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. CK17 is expressed in the… More details
Product Overview
Online Datasheet in PDFProduct Name
Cytokeratin 17 (KRT17), Monoclonal Antibody
Full Product Name
Cytokeratin 17 (K17, Keratin Type I Cytoskeletal 17, Keratin-17, KRT17, PCHC1) (AP)
Product Gene Name
anti-KRT17 antibody
Product Synonym Names
K17; Keratin Type I Cytoskeletal 17; Keratin-17; KRT17; PCHC1
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
SPM560
Host
Mouse
Species Reactivity
Bovine, Goat, Human, Porcine, Rat
Form/Format
Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A/G Affinity Chromatography.
Specificity
Recognizes rat Cytokeratin 17. Species Crossreactivity: human, bovine, goat, porcine
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
48,106 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (39775692..39780882, complement). Location: 17q21.2
OMIM
148069
Immunogen
The cytoskeletal fraction of rat colon epithelium (Q04695; Q6IFU8). Cellular Localization: Cytoplasmic
Conjugate
AP
Positive Control
Skin
Product Categories/Family for anti-KRT17 antibody
Antibodies; Cytokeratin
Applications Tested/Suitable for anti-KRT17 antibody
ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-KRT17 antibody
Applications are based on unconjugated antibody.
Product References and Citations for anti-KRT17 antibody
1. Smedts et. al. Am J Pathol 141: 497, 1992. 2. Smedts et. al. Am J Pathol 140: 601, 1992. 3. Wetzels et. al. Histopathol 20: 295, 1992.
Other Notes
Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for KRT17 purchase
MBS6124096 is an antibody targeting KRT17. Also known as Cytokeratin 17 (K17, Keratin Type I Cytoskeletal 17, Keratin-17, KRT17, PCHC1) (AP). Reactive in Bovine, Goat, Human, Porcine, Rat. Host: Mouse.
Additional Details
NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17
NCBI Official Synonym Symbols
PC; K17; PC2; PCHC1
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17
Protein Family
Keratin
UniProt Gene Name
KRT17
UniProt Synonym Gene Names
CK-17; K17
UniProt Entry Name
K1C17_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 17; 39.1; CK-17; keratin-17; cytokeratin-17; keratin 17 epitope S1; keratin 17 epitope S2; keratin 17 epitope S4
NCBI Summary for KRT17
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
UniProt Comments for KRT17
K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; intermediate filament
Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding
Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth
Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2
Show more Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; intermediate filament
Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding
Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth
Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2
Research Articles on KRT17
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-KRT17 antibody
| Reference Product | PubMed Publications |
|---|---|
| KRT6A antibody | >17 publications with KRT17 and KRT6A |
| KRT7 antibody | >1 publications with KRT17 and KRT7 |
Pathways associated with anti-KRT17 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| EGFR1 Signaling Pathway antibodies | EGFR1 Signaling Pathway Diagram |
| Glucocorticoid Receptor Regulatory Network Pathway antibodies | Glucocorticoid Receptor Regulatory Network Pathway Diagram |
Diseases associated with anti-KRT17 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Pachyonychia congenita Jackson Lawler type Antibodies | >20 publications with KRT17 and Pachyonychia congenita Jackson Lawler type |
| Neoplasms Antibodies | >19 publications with KRT17 and Neoplasms |
| Adenocarcinoma Antibodies | >7 publications with KRT17 and Adenocarcinoma |
| Carcinoma, Squamous Cell Antibodies | >7 publications with KRT17 and Carcinoma, Squamous Cell |
| Breast Neoplasms Antibodies | >5 publications with KRT17 and Breast Neoplasms |
| Pain Antibodies | >4 publications with KRT17 and Pain |
| Skin Neoplasms Antibodies | >3 publications with KRT17 and Skin Neoplasms |
| Carcinoma, Basal Cell Antibodies | >2 publications with KRT17 and Carcinoma, Basal Cell |
| Esophageal Squamous Cell Carcinoma Antibodies | >2 publications with KRT17 and Esophageal Squamous Cell Carcinoma |
| Precancerous Conditions Antibodies | >1 publications with KRT17 and Precancerous Conditions |
Organs/Tissues associated with anti-KRT17 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Skin Antibodies | >16 publications with KRT17 and Skin |
| Mouth Antibodies | >3 publications with KRT17 and Mouth |
| Lymph Antibodies | >2 publications with KRT17 and Lymph |
| Mammary Gland Antibodies | >2 publications with KRT17 and Mammary Gland |
| Lymph Node Antibodies | >2 publications with KRT17 and Lymph Node |
| Intestine Antibodies | >1 publications with KRT17 and Intestine |
| Bladder Antibodies | >1 publications with KRT17 and Bladder |
| Prostate Antibodies | >1 publications with KRT17 and Prostate |
| Muscle Antibodies | >1 publications with KRT17 and Muscle |
| Pancreas Antibodies | >1 publications with KRT17 and Pancreas |