Conduritol B epoxide [6090-95-5]

Biological Activity

Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor.

Chemical Information

Molecular Weight	162.14
CAS Number	6090-95-5
Form	Solid
Solubility (25°C)	Water 90 mg/mL DMSO 50 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Junghyun Jo, et al. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations

[2] Chi-Lin Kuo, et al. In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling

[3] M C Stephens, et al. Distribution of conduritol B epoxide in the animal model for Gaucher's disease (Gaucher mouse)

[4] D S Newburg, et al. Macrophages exposed in vitro to conduritol B epoxide resemble Gaucher cells

[5] M Adachi, et al. Gaucher disease in mice induced by conduritol-B-epoxide: morphologic features