CDKN1A Antibody - N-terminal region
Referência ARP30198_P050
Tamanho : 100ul
Marca : Aviva Systems Biology
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CDKN1A Antibody - N-terminal region (ARP30198_P050)
| Datasheets/Manuals | Printable datasheet for anti-CDKN1A (ARP30198_P050) antibody |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | IHC |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N-terminal region of Human CDKN1A |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 92%; Guinea Pig: 92%; Horse: 83%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 92%; Rat: 100%; Sheep: 100%; |
| Peptide Sequence | Synthetic peptide located within the following region: KACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAW |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-CDKN1A (ARP30198_P050) antibody is Catalog # AAP30198 |
| Gene Symbol | CDKN1A |
|---|---|
| Gene Full Name | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| Alias Symbols | P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1 |
| NCBI Gene Id | 1026 |
| Protein Name | Cyclin-dependent kinase inhibitor 1 |
| Description of Target | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. |
| Uniprot ID | Q6FI05 |
| Protein Accession # | NP_510867 |
| Nucleotide Accession # | NM_078467 |
| Protein Size (# AA) | 164 |
| Molecular Weight | 18kDa |
| Protein Interactions | CCND1; PCNA; KRT31; TRIM54; TEX11; IKZF3; UBC; TRAF1; TCF4; SKP2; CCND3; CCND2; PHKG2; PHKA1; NCL; HSPA9; HSPA8; HSPA5; HSPA2; HSPA1A; HNRNPA2B1; CDK2; CDK5; CDK4; CDK3; CDC20; CCNE1; CCNB1; CCNA2; CAMK2D; ABR; GIGYF2; ANKRD17; UBR4; SNRNP200; FBXO21; PUF |
