CBS
Referência ARP45746_T100
Tamanho : 100ul
Marca : Aviva Systems Biology
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CBS Antibody - N-terminal region (ARP45746_T100)
| Datasheets/Manuals | Printable datasheet for anti-CBS (ARP45746_T100) antibody |
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| Publications | The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio) |
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| Tested Species Reactivity | Human, Mouse, Rat |
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | IHC, WB |
| Additional Information | IHC Information: Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%. |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human CBS |
| Purification | Protein A purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 93% |
| Peptide Sequence | Synthetic peptide located within the following region: RCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNE |
| Concentration | 1.0 mg/ml |
| Blocking Peptide | For anti-CBS (ARP45746_T100) antibody is Catalog # AAP45746 (Previous Catalog # AAPP26703) |
| Enhanced Validation | Relative Expression (Western Blot)  |
| Reference | Urreizti,R., (2006) J. Hum. Genet. 51 (4), 305-313 |
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| Gene Symbol | CBS |
| Gene Full Name | Cystathionine-beta-synthase |
| Alias Symbols | CBSL, HIP4 |
| NCBI Gene Id | 875 |
| Protein Name | Cystathionine beta-synthase |
| Description of Target | CBS is involved in the transsulfuration pathway. The first step of this pathway, from homocysteine to cystathionine, is catalyzed by this protein. CBS deficiency can cause homocystinuria which affects many organs and tissues, including the eyes and the skeletal, vascular and central nervous systems.The protein encoded by this gene is involved in the transsulfuration pathway. The first step of this pathway, from homocysteine to cystathionine, is catalyzed by this protein. CBS deficiency can cause homocystinuria which affects many organs and tissues, including the eyes and the skeletal, vascular and central nervous systems. |
| Uniprot ID | P35520 |
| Protein Accession # | NP_000062 |
| Nucleotide Accession # | NM_000071 |
| Protein Size (# AA) | 551 |
| Molecular Weight | 61 kDa |
| Protein Interactions | UBASH3A; UBE2I; PSMA1; PRKAG1; PIN1; EHHADH; CBS; SUMO1; UBC; NEDD8; PIAS3; RANBP9; PIAS1; CBX4; SRP14; RAD23B; PKM; NUCB1; IREB2; HSF1; LRSAM1; C14orf142; UBA5; IPO4; GOPC; PARP6; NPLOC4; DERA; ERO1L; DBNL; GPN1; PDLIM5; PLIN3; UBA2; GPSM1; COL4A3BP; UGP |
