Quimigen Portugal > Caspase 8 (CASP8) (NM_001080125) Human Recombinant Protein
Caspase 8 (CASP8) (NM_001080125) Human Recombinant Protein
Referência TP760927
Tamanho : 50µg
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Caspase 8 (CASP8) (NM_001080125) Human Recombinant Protein
SKU
TP760927
Purified recombinant protein of Human caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant G, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | Protein Sequence A DNA sequence encoding human full-length CASP8 |
| Tag | N-His |
| Predicted MW | 61.7 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001073594 |
| Locus ID | 841 |
| UniProt ID | Q14790 |
| Cytogenetics | 2q33.1 |
| RefSeq Size | 2938 |
| RefSeq ORF | 1614 |
| Synonyms | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 |
| Summary | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Alzheimer's disease, Apoptosis, Huntington's disease, NOD-like receptor signaling pathway, p53 signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Viral myocarditis |
| FAQs |
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| SDS |
| Recombinant Protein Resources |
| SKU | Description | Size | ||
|---|---|---|---|---|
| LC403245 | CASP8 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug | | |
| LC420061 | CASP8 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug | | |
| LY403245 | Transient overexpression lysate of caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant B | 100 ug | | |
| LY420061 | Transient overexpression lysate of caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant A | 100 ug | | |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.