BNIP2 Antibody
Referência CSB-PA050117-100ug
Tamanho : 100ug
Marca : Cusabio
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Telefone : +1 850 650 7790
Product Details
Uniprot No.
Target Names
BNIP2
Alternative Names
BCL2/adenovirus E1B 19 kDa protein interacting protein 2 antibody; BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 antibody; BCL2/adenovirus E1B 19kDa interacting protein 2 antibody; BNIP 2 antibody; Bnip2 antibody; BNIP2_HUMAN antibody; NIP2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the C-terminal region of Human BNIP-2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IF, FCM, ELISA
Recommended Dilution
| Application | Recommended Dilution |
|---|---|
| WB | 1:500-1:2000 |
| IF | 1:200-1:1000 |
| FC | 1:200-1:400 |
| ELISA | 1:40000 |
Protocols
FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Customer Reviews and Q&A
There are currently no reviews for this product.
Target Background
Function
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
Gene References into Functions
- BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine.
- BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain.
- Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2.
- Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing.
- Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells
- BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1
- BNIP-2 in vivo induces cell dynamics by recruiting Cdc42
- Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities.
Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.
Database Links
HGNC:
OMIM:
KEGG:
STRING:
UniGene: