AP1903 (Rimiducid) [195514-63-7]

Biological Activity

Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. In vivo, Rimiducid (0.01, 0.1, 1, 10, and 100 mg/kg; i.v.) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information

Molecular Weight	1411.63
Formula	C78H98N4O20
CAS Number	195514-63-7
Solubility (25°C)	DMSO 48 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] D C Thomis, et al. Blood. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

[2] T Clackson, et al. Proc Natl Acad Sci U S A. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity