Anti-Human FSH [Clone 181] - HRP

Purified Recombinant Human Follicle Stimulating Hormone Beta (>98%)

This horseradish peroxidase conjugate is supplied in a specially formulated stabilization diluent.(Leinco Prod. No.: S509)

Stable for at least one year when stored at 2°C 8°C. Do not freeze.

Paired with Leinco Prod. No. F103, Clone No. 176: FSH 100%, BhCG <1%, LH <4%, ihCG*, TSH <1% *3,000 mlU/ml hCG causes 4.5% decrease in observed FSH. At higher concentrations of hCG, observed FSH reduced to zero. Paired with Leinco Prod. No. C102, Clone No. 151: FSH 100%, BhCG <1%, ihCG **, FSH <1%, TSH <1%.** At high concentrations of hCG, observed FSH reduced to zero.

Next Day 28°C

Mouse AntiHuman Follicle Stimulating Hormone β (Clone 181) recognizes Human Follicle Stimulating Hormone β. This monoclonal antibody was purified using multistep affinity chromatography methods such as Protein A or G depending on the species and isotype.

Folliclestimulating hormone (FSH) is a heterodimeric glycoprotein and is composed of alpha and beta subunits. Alpha subunit is common to FSH and LH, while a unique beta subunit determines the biological specificity of each hormone. The synthesis of beta subunit is the primary ratelimiting step in the synthesis of each hormone.¹ Human mutations in the FSH beta gene have been shown to produce complete deficiency states in which pubertal development and reproductive capacity are inhibited.²

1. Ryu KZ et al. (2000) J Korean Soc Endocrinol. 15: 179 2. Sluss Patrick et al. (2002) J clin endocrin and metabolism 87: 3702