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Anti-Ficolin 2 Polyclonal Antibody

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Referência NB-64-155979-100uL

Tamanho : 100uL

Marca : Neo Biotech

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Anti-Ficolin 2 Polyclonal Antibody

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Synonyms:

Catalog No. TMAB-06029 Copy Product Info
Anti-Ficolin 2 Polyclonal Antibody is a Rabbit antibody targeting Ficolin 2. Anti-Ficolin 2 Polyclonal Antibody can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-Ficolin 2 Polyclonal Antibody is a Rabbit antibody targeting Ficolin 2. Anti-Ficolin 2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat)
Verified Activity
Sample:
Liver (Mouse) Lysate at 40 μg
HepG2 (human) Lysate at 40 μg
Primary: Anti-Ficolin 2 (TMAB-06029) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted.
Tissue SpecificityExpressed by the liver and secreted in plasma.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundFicolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Behçet's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Ficolin 2/Ficolin B
Antigen Species
Human
Gene Name
FCN2
Gene ID
2220
Protein Name
Ficolin-2
Uniprot ID
Q15485
Function
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.
Chemical Properties
Molecular WeightTheoretical: 31 kDa. Actual: 31 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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