General Information
| Short Description | Mouse monoclonal anti-CD49d for use in IHC-F, FC and IP in Human, Rat, Monkey, Bovine, Pig, Goat, Rabbit, Horse and Rabbit samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/FC/IP |
| Host | Mouse |
| Reactivity | Human/Rat/Monkey/Bovine/Pig/Goat/Rabbit/Horse/Rabbit |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | HP2/1 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Formulation | PBS with <0.1% sodium azide |
| Storage Instruction | Store aliquots at-20°C, and thawed aliquots at 2-8°C. |
Target Information
| Immunogen | JM leukaemia line |
Additional Info
| Background | Mouse anti Human CD49d monoclonal antibody, clone HP2/1 recognizes human CD49d also known as integrin alpha-4 or VLA-4 subunit alpha. CD49d is a ~150kDa single pass type 1 transmembrane glycoprotein with seven FG-GAP repeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa (Hemler et al. 1987). CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form the Peyer s patch-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue (Sackstein 2006) through its interaction with MadCam-1, preferentially expressed on Peyer s patch high endothelial venules and postcapillary venules in lamina propria (Briskin et al. 1997). |
Information sourced from Uniprot.org