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| Gene : | IL2RB |
| Gene ID : | 3560 |
| Uniprot ID : | P14784 |
| Alternative Name : | IL2RB, IL15RB |
| Immunogen Information : | TL-Mor cell line |
CD122 (IL-2/IL-15R beta) constitutes together with CD132 (common gamma chain) and with CD25 (IL-2/IL15R alpha) the intermediate (CD122+CD132) and the high affinity (CD122+CD132+CD25) IL-2 and IL-15 receptor complex. CD122 is expressed on NK cells and lymphocytes, but at low level, unless the cell is activated. The cytoplasmic part of CD122 binds to Src-family and Jak-family kinases. The biological effect of CD122 ligation depends on whether IL-2 or IL-15 is bound to the receptor complex.
| Subcellular location: | Membrane |
| BioGrid: | 109775. 18 interactions. |
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