| Short Description : | Mouse monoclonal anti-Immunoglobulin Superfamily Member 2 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | BB27 |
| Isotype: | IgG1k |
| Conjugation: | PerCP/Cyanine 5.5 |
| Concentration: | 5 Mu L/Test |
| Purification: | Affinity purified |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction: | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Gene Symbol: | |
| Gene ID: | |
| Uniprot ID: |
| Tissue Specificity | Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. |
| Protein Name | Immunoglobulin Superfamily Member 2Igsf2Cell Surface Glycoprotein V7Glu-Trp-Ile Ewi Motif-Containing Protein 101Ewi-101Cd Antigen Cd101 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Immunoglobulin Superfamily Member 2 antibodyAnti-Igsf2 antibodyAnti-Cell Surface Glycoprotein V7 antibodyAnti-Glu-Trp-Ile Ewi Motif-Containing Protein 101 antibodyAnti-Ewi-101 antibodyAnti-Cd Antigen Cd101 antibodyAnti-CD101 antibodyAnti-EWI101 antibodyAnti-IGSF2 antibodyAnti-V7 antibody |
Information sourced from Uniprot.org